HiCuT: Efficient 3D Genome Profiling with Fewer Cells
Less is More: A Revolution in 3D Genome Mapping Traditional 3D genome mapping techniques require substantial cell numbers and extensive sequencing, limiting their applicability and increasing costs. HiCuT (High-throughput Chromosome Conformation Capture using Targeted sequencing), however, offers a significant advancement by achieving comparable results with dramatically reduced resource requirements. This innovative method leverages a streamlined approach, resulting in up to a five-fold reduction in the number of cells needed and an eight-fold reduction in sequencing reads compared to existing techniques....